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Medical research

Trial unpredictability yields predictable therapy gains

Nature volume 500, pages 395396 (22 August 2013) | Download Citation

In decades of clinical-trial data, new treatments are better than standard ones just over half the time. That's as it should be, say Benjamin Djulbegovic and colleagues.

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Author information


  1. Benjamin Djulbegovic is professor in the Department of Internal Medicine, University of South Florida (USF), Tampa, and at the H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.

    • Benjamin Djulbegovic
  2. Ambuj Kumar is associate professor at the Department of Internal Medicine, USF and at the H. Lee Moffitt Cancer Center and Research Institute.

    • Ambuj Kumar
  3. Paul Glasziou is professor of evidence-based medicine at Bond University, Robina, Australia.

    • Paul Glasziou
  4. Branko Miladinovic is assistant professor in the Department of Internal Medicine, USF.

    • Branko Miladinovic
  5. Iain Chalmers is coordinator of the James Lind Initiative, Oxford, UK.

    • Iain Chalmers


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Corresponding author

Correspondence to Benjamin Djulbegovic.

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