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Evolutionary biology

The handiwork of tinkering

A comparison of regulatory DNA sequences in humans, macaques and mice during embryonic limb development reveals thousands of sites of enhanced regulatory activity that are likely to have driven the evolution of our characteristic anatomy.

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Figure 1: The evolutionary origins of mammalian and human limb development.

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Correspondence to Paul Flicek.

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Flicek, P. The handiwork of tinkering. Nature 500, 158–159 (2013). https://doi.org/10.1038/500158a

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