Whole-genome sequencing of human malaria parasites has revealed genomic regions that are associated with resistance to artemisinin-based drugs. The findings may help to explain the origin and spread of this worrying trend.
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References
Murray, C. J. L. et al. Lancet 379, 413–431 (2012).
World Malaria Report 2012 (World Health Organization, 2012).
Noedl, H. et al. N. Engl. J. Med. 359, 2619–2620 (2008).
Miotto, O. et al. Nature Genet. 45, 648–655 (2013).
Eastman, R. T. & Fidock, D. A. Nature Rev. Microbiol. 7, 864–874 (2009).
Roper, C. et al. Science 305, 1124 (2004).
Payne, D. Parasitol. Today 3, 241–246 (1987).
Mita, T. et al. J. Infect. Dis. 204, 1980–1988 (2011).
Cheeseman, I. H. et al. Science 336, 79–82 (2012).
Takala-Harrison, S. et al. Proc. Natl Acad. Sci. USA 110, 240–245 (2013).
Durai, S. et al. Nucleic Acids Res. 33, 5978–5990 (2005).
Straimer, J. et al. Nature Meth. 9, 993–998 (2012).
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Bright, A., Winzeler, E. Resistance mapping in malaria. Nature 498, 446–447 (2013). https://doi.org/10.1038/498446b
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DOI: https://doi.org/10.1038/498446b
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