Cells can sense and respond to fluctuations in nutrient availability. Mutations that disrupt such lines of nutrient communication with the cellular growth machinery seem to contribute to the uncontrolled growth of cancer cells.
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Bar-Peled, L. et al. Science 340, 1100–1106 (2013).
Laplante, M. & Sabatini, D. M. Cell 149, 274–293 (2012).
Dibble, C. C. & Manning, B. D. Nature Cell Biol. 15, 555–564 (2013).
Neklesa, T. K. & Davis, R. W. PLoS Genet. 5, e1000515 (2009).
Panchaud, N., Péli-Gulli, M. P. & De Virgilio, C. Sci. Signal. 6, ra42 (2013).
Menon, S. & Manning, B. D. Oncogene 27, S43–S51 (2008).
Li, J. et al. Cancer Res. 64, 6438 (2004).
Leprivier, G. et al. Cell 153, 1064–1079 (2013).
Shackelford, D. B. et al. Cancer Cell 23, 143–158 (2013).
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Menon, S., Manning, B. Nutrient sensing lost in cancer. Nature 498, 444–445 (2013). https://doi.org/10.1038/498444a