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Medical research: Cell division

In 1962, Leonard Hayflick created a cell strain from an aborted fetus. More than 50 years later, WI-38 remains a crucial, but controversial, source of cells.

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  1. Hayflick, L. & Moorhead, P. S. Exp. Cell Res. 25, 585–621 (1961).

    Article  CAS  Google Scholar 

  2. Hayflick, L. Exp. Cell Res. 37, 614–636 (1965).

    Article  CAS  Google Scholar 

  3. Cristofalo, V. J. & Kritchevsky, D. J. Cell Physiol. 67, 125–132 (1966).

    Article  CAS  Google Scholar 

  4. Kritchevsky, D. & Howard, B. V. Ann. Med. Exp. Biol. Fenn. 44, 343–347 (1966).

    CAS  PubMed  Google Scholar 

  5. Freestone, D. S., Reynolds, G. M., McKinnon, J. A. & Prydie, J. Br. J. Prev. Soc. Med. 29, 258–261 (1975).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Hayflick, L., Plotkin, S. A., Norton, T. W. & Koprowski, H. Am. J. Hyg. 75, 240–258 (1962).

    CAS  PubMed  Google Scholar 

  7. Wade, N. Science 192, 125–127 (1976).

    Article  ADS  CAS  Google Scholar 

  8. Calabretta, B. et al. Proc. Natl Acad. Sci. USA 82, 4463–4467 (1985).

    Article  ADS  CAS  Google Scholar 

  9. Sugarman, B. J. et al. Science 230, 943–945 (1985).

    Article  ADS  CAS  Google Scholar 

  10. Dimri, G. P. et al. Proc. Natl Acad. Sci. USA 92, 9363–9367 (1995).

    Article  ADS  CAS  Google Scholar 

  11. Zhang, R. et al. Dev. Cell 8, 19–30 (2005).

    Article  CAS  Google Scholar 

  12. Kominers, S. D. & Becker, G. S. Science 337, 1292–1293 (2012).

    Article  ADS  CAS  Google Scholar 

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Additional information

See Editorial page 407.

Related video

California boundLeonard Hayflick talks about his decision to take ampoules of WI-38 cells from the Wistar Institute to Stanford University. Courtesy: Web of Stories

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Biobanks: Validate gene findings before telling donors 2012-Apr-25

Incidental benefits 2012-Mar-21

Hayflick, his limit, and cellular ageing 2000-Oct-01

Related external links

Science poll results on whether redundant tissue donors should be paid

Science policy forum on tissue donor compensation

Hayflick’s letter to Science

ATCC catalogue entry for WI-38

Article by Rebecca Skloot on the publication of the HeLa genome

Recordings made by Hayflick for Web of Stories

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Wadman, M. Medical research: Cell division. Nature 498, 422–426 (2013).

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