Mutations in the enzyme isocitrate dehydrogenase lead to the accumulation of a metabolite that seems to promote cancer by influencing the epigenetic status of cells. But the effects are reversible, hinting at therapeutic targets.
This is a preview of subscription content, access via your institution
Open Access articles citing this article.
Oncogenesis Open Access 14 February 2020
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
Dang, L. et al. Nature 462, 739–744 (2009).
Ward, P. S. et al. Cancer Cell 17, 225–234 (2010).
Losman, J. A. et al. Science http://dx.doi.org/10.1126/science.1231677 (2013).
Parsons, D. W. et al. Science 321, 1807–1812 (2008).
Mardis, E. R. et al. N. Engl. J. Med. 361, 1058–1066 (2009).
Koivunen, P. et al. Nature 483, 484–488 (2012).
Xu, W. et al. Cancer Cell 19, 17–30 (2011).
Lu, C. et al. Nature 483, 474–478 (2012).
Figueroa, M. E. et al. Cancer Cell 18, 553–567 (2010).
Turcan, S. et al. Nature 483, 479–483 (2012).
Moran-Crusio, K. et al. Cancer Cell 20, 11–24 (2011).
Song, L.-P. et al. Oncogene 27, 519–527 (2008).
Friedman, A. D. Oncogene 21, 3377–3390 (2002).
H.R.C owns equity in Agios, a biotechnology company developing IDH inhibitors.
About this article
Cite this article
Krall, A., Christofk, H. A metabolic metamorphosis. Nature 496, 38–40 (2013). https://doi.org/10.1038/496038a
This article is cited by
Mitochondrial oxidative phosphorylation became functional under aglycemic hypoxia conditions in A549 cells
Molecular Biology Reports (2022)
Nature Cell Biology (2017)
Journal of Bioenergetics and Biomembranes (2015)