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A metabolic metamorphosis

Mutations in the enzyme isocitrate dehydrogenase lead to the accumulation of a metabolite that seems to promote cancer by influencing the epigenetic status of cells. But the effects are reversible, hinting at therapeutic targets.

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Figure 1: An oncogenic metabolite.


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Correspondence to Abigail S. Krall or Heather R. Christofk.

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Competing interests

H.R.C owns equity in Agios, a biotechnology company developing IDH inhibitors.

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Krall, A., Christofk, H. A metabolic metamorphosis. Nature 496, 38–40 (2013).

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