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Positive and radical

Biosynthesis of the antibiotic fosfomycin ends with the formation of an 'epoxide' ring structure. The epoxide is suggested to form from a cationic intermediate, rather than from a free radical. See Letter p.114

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Figure 1: Reactions catalysed by the (S)-2-hydroxypropylphosphonate epoxidase (HppE) enzyme.
Figure 2: Proposed mechanisms of HppE-catalysed reactions.


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Correspondence to Wilfred A. van der Donk.

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Peck, S., van der Donk, W. Positive and radical. Nature 496, 34–35 (2013).

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