Biosynthesis of the antibiotic fosfomycin ends with the formation of an 'epoxide' ring structure. The epoxide is suggested to form from a cationic intermediate, rather than from a free radical. See Letter p.114
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Kovaleva, E. G. & Lipscomb, J. D. Nature Chem. Biol. 4, 186–193 (2008).
Chang, W. et al. Nature 496, 114–118 (2013).
Hammerschmidt, F. J. Chem. Soc. Perkin Trans. 1, 1993–1996 (1991).
Liu, P. et al. J. Am. Chem. Soc. 123, 4619–4620 (2001).
Huang, H. et al. J. Am. Chem. Soc. 134, 16171–16174 (2012).
Higgins, L. J., Yan, F., Liu, P., Liu, H. W. & Drennan, C. L. Nature 437, 838–844 (2005).
Groves, J. T. J. Inorg. Biochem. 100, 434–447 (2006).
Cicchillo, R. M. et al. Nature 459, 871–874 (2009).
Metcalf, W. W. et al. Science 337, 1104–1107 (2012).
Rights and permissions
About this article
Cite this article
Peck, S., van der Donk, W. Positive and radical. Nature 496, 34–35 (2013). https://doi.org/10.1038/496034a