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X-ray crystallography

One size fits most

Crystalline 'sponges' offer a way to impose order on small molecules so that their structures can be solved by X-ray crystallography. This enables nanogram quantities of material to be analysed using the technique. See Article p.461

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Figure 1: Order imposed by a framework.



  1. Blow, D. Outline of Crystallography for Biologists (Oxford Univ. Press, 2002).

    Google Scholar 

  2. Inokuma, Y. et al. Nature 495, 461–466 (2013).

    Article  ADS  CAS  Google Scholar 

  3. Sheldrick, G. M. Acta Crystallogr. A 64, 112–122 (2008).

    Article  ADS  CAS  Google Scholar 

  4. Nuzillard, J.-M. & Massiot, G. Tetrahedron 47, 3655–3664 (1991).

    Article  CAS  Google Scholar 

  5. Lederberg, J. et al. J. Am. Chem. Soc. 91, 2973–2976 (1969).

    Article  CAS  Google Scholar 

  6. Molinski, T. F. Nat. Prod. Rep. 27, 321–329 (2010).

    Article  CAS  Google Scholar 

  7. Kitagawa, S., Kitaura, R. & Noro, S.-I. Angew. Chem. Int. Edn 43, 2334–2375 (2004).

    Article  CAS  Google Scholar 

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Correspondence to Jon Clardy.

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Stallforth, P., Clardy, J. One size fits most. Nature 495, 456–457 (2013).

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