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Cancer

Stress mixes chromosomes

Chromosome-segregation errors during cell division may play a key part in tumour evolution. The long-awaited identification of a common genetic defect causing such errors comes with an interesting conceptual twist. See Letter p.492

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Figure 1: Replication stress causes chromosomal abnormalities.

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Correspondence to René H. Medema.

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Janssen, A., Medema, R. Stress mixes chromosomes. Nature 494, 439–441 (2013). https://doi.org/10.1038/494439a

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