Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Structural biology

Insulin meets its receptor

The hormone insulin has a central role in human physiology, yet the answer to a fundamental biochemical question — how it binds to its cell-surface receptor — has remained elusive, until now. See Letter p.241

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Binding of insulin to its receptor.

References

  1. Ward, C. W. & Lawrence, M. C. Front. Endocrinol. 2, 76 (2011).

    Article  Google Scholar 

  2. Menting, J. G. et al. Nature 493, 241–245 (2013).

    Article  ADS  CAS  Google Scholar 

  3. Stroud, R. M. & Wells, J. A. Sci. STKE 2004, re7 (2004).

    PubMed  Google Scholar 

  4. Wang, X., Lupardus, P., Laporte, S. L. & Garcia, K. C. Annu. Rev. Immunol. 27, 29–60 (2009).

    Article  Google Scholar 

  5. Lemmon, M. A. & Schlessinger, J. Cell 141, 1117–1134 (2010).

    Article  CAS  Google Scholar 

  6. Hubbard, S. R. & Miller, W. T. Curr. Opin. Cell Biol. 19, 117–123 (2007).

    Article  CAS  Google Scholar 

  7. De Meyts, P. Trends Biochem. Sci. 33, 376–384 (2008).

    Article  CAS  Google Scholar 

  8. McKern, N. M. et al. Nature 443, 218–221 (2006).

    Article  ADS  CAS  Google Scholar 

  9. Pandyarajan, V. & Weiss, M. A. Curr. Diab. Rep. 12, 697–704 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Stevan R. Hubbard.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hubbard, S. Insulin meets its receptor. Nature 493, 171–172 (2013). https://doi.org/10.1038/493171a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/493171a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing