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Metabolism in 'the driver's seat

It is increasingly accepted that metabolic changes in cancer cells can drive tumour formation. The finding that the SIRT6 protein suppresses tumour formation by regulating metabolism adds weight to this view.

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Figure 1: On the road to cancer.


  1. Levine, A. J. & Puzio-Kuter, A. M. Science 330, 1340–1344 (2010).

    ADS  CAS  Article  Google Scholar 

  2. Sebastián, C. et al. Cell 151, 1185–1199 (2012).

    Article  Google Scholar 

  3. Tennen, R. I. & Chua, K. F. Trends Biochem. Sci. 36, 39–46 (2011).

    CAS  Article  Google Scholar 

  4. Hanahan, D. & Weinberg, R. A. Cell 144, 646–674 (2011).

    CAS  Article  Google Scholar 

  5. Hahn, W. C. et al. Nature 400, 464–468 (1999).

    ADS  CAS  Article  Google Scholar 

  6. Min, L. et al. Nature Cell Biol. 14, 1203–1211 (2012).

    CAS  Article  Google Scholar 

  7. Xiao, C. et al. J. Biol. Chem. 287, 41903–41913 (2012).

    CAS  Article  Google Scholar 

  8. Kanfi, Y. et al. Nature 483, 218–221 (2012).

    ADS  CAS  Article  Google Scholar 

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Correspondence to Katrin F. Chua.

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Tasselli, L., Chua, K. Metabolism in 'the driver's seat. Nature 492, 362–363 (2012).

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