Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cell biology

All clear for ribosome landing

The discovery of a dramatic structural rearrangement that is stabilized by an RNA scaffold helps to explain how nascent proteins are delivered for export from the cell cytoplasm. See Letter p.271

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Handover of translating ribosomes.


  1. Shen, K., Arslan, S., Akopian, D., Ha, T. & Shan, S. O. Nature 492, 271–275 (2012).

    ADS  CAS  Article  Google Scholar 

  2. Bradshaw, N., Neher, S. B., Booth, D. S. & Walter, P. Science 323, 127–130 (2009).

    ADS  CAS  Article  Google Scholar 

  3. Shan, S., Stroud, R. M. & Walter, P. PLoS Biol. 2, e320 (2004).

    Article  Google Scholar 

  4. Zhang, X., Schaffitzel, C., Ban, N. & Shan, S. Proc. Natl Acad. Sci. USA 106, 1754–1759 (2009).

    ADS  CAS  Article  Google Scholar 

  5. Angelini, S., Deitermann, S. & Koch, H. G. EMBO Rep. 6, 476–481 (2005).

    CAS  Article  Google Scholar 

  6. Gu, S.-Q., Peske, F., Wieden, H.-J., Rodnina, M. V. & Wintermeyer, W. RNA 9, 566–573 (2003).

    CAS  Article  Google Scholar 

  7. Ataide, S. F. et al. Science 331, 881–886 (2011).

    ADS  CAS  Article  Google Scholar 

  8. Shen, K. & Shan, S. Proc. Natl Acad. Sci. USA 107, 7698–7703 (2010).

    ADS  CAS  Article  Google Scholar 

  9. Newitt, J. A. & Bernstein, H. D. Eur. J. Biochem. 245, 720–729 (1997).

    CAS  Article  Google Scholar 

  10. Batey, R. T., Rambo, R. P., Lucast, L., Rha, B. & Doudna, J. A. Science 287, 1232–1239 (2000).

    ADS  CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Harris D. Bernstein.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Bernstein, H. All clear for ribosome landing. Nature 492, 189–191 (2012).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing