Researchers have coaxed cultured embryonic stem cells to develop into eggs that then give rise to normal offspring. The discovery should help to decode the molecular basis of gamete formation and might lead to treatments for infertility.
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Hayashi, K. et al. Science 338, 971–975 (2012).
Hayashi, K., Ohta, H., Kurimoto, K., Aramaki, S. & Saitou, M. Cell 146, 519–532 (2011).
Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).
Daley, G. Q. Science 316, 409–410 (2007).
Surani, M. A. & Hajkova, P. Cold Spring Harb. Symp. Quant. Biol. 75, 211–218 (2010).
Buganim, Y. et al. Cell Stem Cell 11, 373–386 (2012).
Rights and permissions
About this article
Cite this article
Cheloufi, S., Hochedlinger, K. Stem cells bear eggs. Nature 491, 535–536 (2012). https://doi.org/10.1038/491535a