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Reproductive biology

Stem cells bear eggs

Researchers have coaxed cultured embryonic stem cells to develop into eggs that then give rise to normal offspring. The discovery should help to decode the molecular basis of gamete formation and might lead to treatments for infertility.

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Figure 1: Oogenesis from cultured stem cells.


  1. Hayashi, K. et al. Science 338, 971–975 (2012).

    Article  ADS  CAS  Google Scholar 

  2. Hayashi, K., Ohta, H., Kurimoto, K., Aramaki, S. & Saitou, M. Cell 146, 519–532 (2011).

    Article  CAS  Google Scholar 

  3. Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    Article  CAS  Google Scholar 

  4. Daley, G. Q. Science 316, 409–410 (2007).

    Article  ADS  CAS  Google Scholar 

  5. Surani, M. A. & Hajkova, P. Cold Spring Harb. Symp. Quant. Biol. 75, 211–218 (2010).

    Article  CAS  Google Scholar 

  6. Buganim, Y. et al. Cell Stem Cell 11, 373–386 (2012).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Konrad Hochedlinger.

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Cheloufi, S., Hochedlinger, K. Stem cells bear eggs. Nature 491, 535–536 (2012).

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