Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Structural biology

A toolbox for protein design

Some of the principles underlying how amino-acid sequences determine the three-dimensional structures of proteins have been defined. This has enabled a successful approach to designing protein folds from scratch. See Article p.222

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: Protein assembly demystified.


  1. Koga, N. et al. Nature 491, 222–227 (2012).

    Article  ADS  CAS  Google Scholar 

  2. Leopold, P. E., Montal, M. & Onuchic, J. N. Proc. Natl Acad. Sci. USA 89, 8721–8725 (1992).

    Article  ADS  CAS  Google Scholar 

  3. Ramachandran, G. N., Ramakrishnan, C. & Sasisekharan, V. J. Mol. Biol. 7, 95–99 (1963).

    Article  CAS  Google Scholar 

  4. Kuhlman, B. et al. Science 302, 1364–1368 (2003).

    Article  ADS  CAS  Google Scholar 

  5. Röthlisberger, D. et al. Nature 453, 190–195 2008).

    Article  ADS  Google Scholar 

  6. Korendovych, I. V. et al. Proc. Natl Acad. Sci. USA 108, 6823–6827 (2011).

    Article  ADS  CAS  Google Scholar 

  7. Baker, D. Protein Sci. 19, 1817–1819 (2010).

    Article  CAS  Google Scholar 

  8. Schreier, B., Stumpp, C., Wiesner, S. & Höcker, B. Proc. Natl Acad. Sci. USA 106, 18491–18496 (2009).

    Article  ADS  CAS  Google Scholar 

  9. Sterner, R. & Höcker, B. Chem. Rev. 105, 4038–4055 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Birte Höcker.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Höcker, B. A toolbox for protein design. Nature 491, 204–205 (2012).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing