Figure 1: Protein assembly demystified. | Nature

Figure 1: Protein assembly demystified.

From: A toolbox for protein design

Figure 1

Proteins are constructed from secondary structures known as α-helices and β-strands, connected by protein loops. Koga et al.1 have defined fundamental rules that describe how local interactions in secondary structures relate to the assembly of simple tertiary motifs (compact, three-dimensional structures that consist of a few adjacent secondary structures, such as the βα- and αβ-motifs shown). In this example, different connecting loops direct the α-helix to pack against different sides of the β-strand. These rules, in turn, form the basis of emergent principles governing the design of 'ideal', more complex motifs, such as the βαβ-structure shown, which is constructed from the βα- and αβ-motifs shown in grey boxes.

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