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Molecular biology

Choose your protein partners

Nature volume 490, pages 351–352 (2012)Cite this article

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A large-scale study sheds light on the extraordinary molecular-recognition skills of the chaperone HSP90, which allow this protein to interact selectively with hundreds of other proteins of diverse function.

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Figure 1: A helping hand for unstable proteins.

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Author information

Authors and Affiliations

  1. Rahul S. Samant and Paul Workman are in the Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, UK.,

    Rahul S. Samant & Paul Workman

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  1. Rahul S. Samant
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  2. Paul Workman
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Correspondence to Paul Workman.

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Competing interests

The authors are at The Institute of Cancer Research, London, UK, which has a commercial interest in HSP90 inhibitors. P.W. received research funding from Vernalis for the discovery of HSP90 inhibitors, and intellectual property from this programme was licensed to Vernalis and Novartis. P.W. was a founder of Chroma Therapeutics and is a scientific advisory board member for Astex Pharmaceuticals and Nextech Invest.

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Samant, R., Workman, P. Choose your protein partners. Nature 490, 351–352 (2012). https://doi.org/10.1038/490351a

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