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Mucosal immunology

Infection induces friendly fire

Our immune system usually ignores 'friendly' gut bacteria. But when infection with a pathogen damages the intestine's mucosal lining, the resident microbes can invade the body, inducing immune responses directed at themselves.

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Figure 1: Breaching the barrier.

References

  1. Hand, T. W. et al. Science 337, 1553–1556 (2012).

    Article  ADS  CAS  Google Scholar 

  2. Pepper, M. & Jenkins, M. K. Nature Immunol. 12, 467–471 (2011).

    Article  CAS  Google Scholar 

  3. Duchmann, R. et al. Clin. Exp. Immunol. 102, 448–455 (1995).

    Article  CAS  Google Scholar 

  4. Khor, B., Gardet, A. & Xavier, R. J. Nature 474, 307–317 (2011).

    Article  CAS  Google Scholar 

  5. Spehlmann, M. E. et al. Inflamm. Bowel Dis. 14, 968–976 (2008).

    Article  Google Scholar 

  6. Lathrop, S. K. et al. Nature 478, 250–254 (2011).

    Article  ADS  CAS  Google Scholar 

  7. Atarashi, K. et al. Science 331, 337–341 (2011).

    Article  ADS  CAS  Google Scholar 

  8. Geuking, M. B. et al. Immunity 34, 794–806 (2011).

    Article  CAS  Google Scholar 

  9. Ivanov, I. I. et al. Cell 139, 485–498 (2009).

    Article  CAS  Google Scholar 

  10. Cadwell, K. et al. Cell 141, 1135–1145 (2010).

    Article  CAS  Google Scholar 

  11. Qin, J. et al. Nature 464, 59–65 (2010).

    Article  CAS  Google Scholar 

Download references

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Correspondence to David Masopust or Vaiva Vezys.

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Masopust, D., Vezys, V. Infection induces friendly fire. Nature 490, 41–43 (2012). https://doi.org/10.1038/490041a

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