Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cancer metabolism

When more is less

A tightly regulated enzyme balances energy production and the synthesis of macromolecules from glucose in cancer cells. Upsetting this balance by stimulating the enzyme's activity can suppress tumour growth in mice.

Your institute does not have access to this article

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: A metabolic bottleneck.

References

  1. Anastasiou, D. et al. Nature Chem. Biol. 8, 839–847 (2012).

    CAS  Article  Google Scholar 

  2. Mazurek, S., Boschek, C. B. & Eigenbrodt, E. J. Bioenerg. Biomembr. 29, 315–330 (1997).

    CAS  Article  PubMed  Google Scholar 

  3. Christofk, H. R. et al. Nature 452, 230–233 (2008).

    ADS  CAS  Article  Google Scholar 

  4. Christofk, H. R., Vander Heiden, M. G., Wu, N., Asara, J. M. & Cantley, L. C. Nature 452, 181–186 (2008).

    ADS  CAS  Article  Google Scholar 

  5. Hitosugi, T. et al. Sci. Signal. 2, ra73 (2009).

    Article  PubMed  Google Scholar 

  6. Lu, C. & Thompson, C. B. Cell Metab. 16, 9–17 (2012).

    CAS  Article  PubMed  Google Scholar 

  7. Luo, W. et al. Cell 145, 732–744 (2011).

    CAS  Article  PubMed  Google Scholar 

  8. Vander Heiden, M. G. et al. Biochem. Pharmacol. 79, 1118–1124 (2010).

    CAS  Article  PubMed  Google Scholar 

  9. Goldberg, M. S. & Sharp, P. A. J. Exp. Med. 209, 217–224 (2012).

    CAS  Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Lei Jiang.

Ethics declarations

Competing interests

L.J. receives salary support from Janssen Pharmaceutica NV, Beerse, Belgium. R.J.D. is a consultant for Agios Pharmaceuticals, Cambridge, Massachusetts, and is on the scientific advisory board of Peloton Therapeutics, Dallas, Texas.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Jiang, L., DeBerardinis, R. When more is less. Nature 489, 511–512 (2012). https://doi.org/10.1038/489511a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/489511a

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing