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Cancer metabolism

When more is less

A tightly regulated enzyme balances energy production and the synthesis of macromolecules from glucose in cancer cells. Upsetting this balance by stimulating the enzyme's activity can suppress tumour growth in mice.

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Figure 1: A metabolic bottleneck.


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Correspondence to Lei Jiang.

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Competing interests

L.J. receives salary support from Janssen Pharmaceutica NV, Beerse, Belgium. R.J.D. is a consultant for Agios Pharmaceuticals, Cambridge, Massachusetts, and is on the scientific advisory board of Peloton Therapeutics, Dallas, Texas.

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Jiang, L., DeBerardinis, R. When more is less. Nature 489, 511–512 (2012).

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