A tightly regulated enzyme balances energy production and the synthesis of macromolecules from glucose in cancer cells. Upsetting this balance by stimulating the enzyme's activity can suppress tumour growth in mice.
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L.J. receives salary support from Janssen Pharmaceutica NV, Beerse, Belgium. R.J.D. is a consultant for Agios Pharmaceuticals, Cambridge, Massachusetts, and is on the scientific advisory board of Peloton Therapeutics, Dallas, Texas.
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Jiang, L., DeBerardinis, R. When more is less. Nature 489, 511–512 (2012). https://doi.org/10.1038/489511a
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DOI: https://doi.org/10.1038/489511a
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