Nano-safety studies urged in China

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Exposure surveys and stronger regulations are required for the industry to thrive, researchers say.

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Nanomaterials, such as carbon nanotubes, are coming under safety scrutiny in China. Credit: PASIEKA/SPL

Here is a recipe for anxiety: take China’s poorly enforced chemical-safety regulations, add its tainted record on product safety and stir in the uncertain risks of a booming nanotechnology industry.

As an antidote to this uneasy mixture, the country should carry out more-extensive safety studies and improve regulatory oversight of synthetic nanomaterials, leading Chinese researchers said at the 6th International Conference on Nanotoxicology in Beijing this month. “This is the only way to maintain the competitiveness of China’s nanotechnology sector,” says Zhao Yuliang, deputy director of the Chinese Academy of Sciences’ National Center for Nano­science and Technology (NCNST) in Beijing. “We certainly don’t want safety issues to become a trade barrier for nano-based products.”

China’s investment in nanotechnology has grown rapidly during the past decade, and its tally of patent applications in the field has surpassed those of Europe and the United States (see ‘Patent boom’). But only 3% of the investment is used for safety studies, says Zhao, compared with about 6% of federal nanotechnology funding in the United States. “The situation must be changed soon,” he says.

Nanoparticles — which measure from 1 to 100 nanometres in diameter — are chemically different from their corresponding bulk mat­erials, and their potential toxicity can vary according to dozens of characteristics, such as size, surface area and coating.

Credit: SOIURCE: PCAST/B. Kisliuk, USTPO. see go.nature.com/mqpWaU

In 2009, researchers claimed that nano­particles were responsible for lung damage in seven workers at a printing factory in Beijing, two of whom subsequently died (see Nature 460, 937; 2009). Volatile organic compounds may actually have been to blame, says Andre Nel, a nanotoxicologist at the University of California, Los Angeles, but such incidents could easily damage the fledgling industry’s reputation. For now, however, the Chinese public remains unconcerned: in a survey led by Wang Guoyu, an ethicist at the Dalian University of Technology, nearly 80% of some 6,000 Chinese respondents said that they are not worried about the safety of nanoparticles.

Researchers at the meeting said that better safety testing was needed for products containing nanoparticles that can be absorbed by the body, such as food and cosmetics in which nanoparticles provide specific colours or textures. But occupational exposure among workers handling the materials may present the greatest risks: China’s workplace safety rules are not always implemented, and they set no specific limits for handling nanoparticles.

“The main challenge is to tease out what characteristics make some nanoparticles hazardous,” says Zhao. To address that question, Chinese researchers will next year join forces with colleagues in Europe, the United States and Brazil in a €13-million (US$17-million) project called Nanosolutions, to develop a nano-safety classification system based on material characteristics, toxicity studies and bioinformatics data. Initially focusing on 30 or so materials, such as carbon nanotubes, and nanoparticles of titanium dioxide and silver, the team will use high-throughput screening to identify the most toxic, and then investigate their biological effects in animal studies.

The data will be used to develop computer software to predict the potential hazards of other nanomaterials — a useful tool for industry and regulators around the world, and “essential to any progress in risk assessment”, says Kai Savolainen, a researcher at the Finnish Institute of Occupational Health in Helsinki, who leads the project. “It will also help the industry to design safe nanomaterials from the outset.”

Studying factory workers who are exposed to nanomaterials could yield further insights. With Chinese exposure levels likely to be much higher than those in Western factories, such surveys are ideally placed to quantify the risks involved, says Dhimiter Bello, an expert in occupational health at the University of Massachusetts in Lowell. Since last year, a team led by the NCNST’s Chen Chunying has been monitoring chemical exposure levels, including those of nanomaterials, in three factories that have varying safety practices. The researchers hope that their data will help the government to draw up regulations covering nanoparticles in the workplace.

As China’s exports are increasingly likely to carry nanotechnology inside them, better regulation is “important not only for safeguarding people, but for the public acceptance of nanotechnology worldwide”, says Nel.

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Qiu, J. Nano-safety studies urged in China. Nature 489, 350 (2012) doi:10.1038/489350a

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