Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cell biology

Dormant and restless skin stem cells

It has been unclear whether a uniform group of stem cells gives rise to most cells in the epidermis. A study reveals the presence of at least two stem-cell populations that have different proliferative abilities. See Article p.257

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Models for self-renewal of the epidermis.

References

  1. Mascré, G. et al. Nature 489, 257–262 (2012).

    Article  ADS  Google Scholar 

  2. Potten, C. S. Cell Tissue Kinet. 7, 77–88 (1974).

    CAS  PubMed  Google Scholar 

  3. Clayton, E. et al. Nature 446, 185–189 (2007).

    CAS  Article  ADS  Google Scholar 

  4. Doupé, D. P . et al. Dev. Cell 18, 317–323 (2010).

    Article  Google Scholar 

  5. Wilson, A. et al. Cell 135, 1118–1129 (2008).

    CAS  Article  Google Scholar 

  6. Barker, N. et al. Nature 449, 1003–1007 (2007).

    CAS  Article  ADS  Google Scholar 

  7. Jaks, V. et al. Nature Genet. 40, 1291–1299 (2008).

    CAS  Article  Google Scholar 

  8. Barrandon, Y. & Green, H. Proc. Natl Acad. Sci. USA 84, 2302–2306 (1987).

    CAS  Article  ADS  Google Scholar 

  9. Pellegrini, G. et al. J. Cell Biol. 145, 769–782 (1999).

    CAS  Article  Google Scholar 

  10. Rama, P. et al. N. Engl. J. Med. 363, 147–155 (2010).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michele De Luca.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

De Rosa, L., De Luca, M. Dormant and restless skin stem cells. Nature 489, 215–217 (2012). https://doi.org/10.1038/489215a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/489215a

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing