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Lessons from heartbreak

Male fruitflies quickly learn that courting already-mated females is useless. It turns out that a small subset of neurons in the male brain signals this negative experience and controls pheromone sensitivity. See Letter p.145

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Figure 1: Fruitfly courtship.



  1. Keleman, K. et al. Nature 489, 145–149 (2012).

    ADS  CAS  Article  Google Scholar 

  2. Hall, J. C. Science 264, 1702–1714 (1994).

    ADS  CAS  Article  Google Scholar 

  3. Siegel, R. W. & Hall, J. C. Proc. Natl Acad. Sci. USA 76, 3430–3434 (1979).

    ADS  CAS  Article  Google Scholar 

  4. Griffith, L. C. & Ejima, A. Learn. Mem. 16, 743–750 (2009).

    Article  Google Scholar 

  5. Busto, G. U., Cervantes-Sandoval, I. & Davis, R. L. Physiology 25, 338–346 (2010).

    CAS  Article  Google Scholar 

  6. Liu, C. et al. Nature 488, 512–516 (2012).

    ADS  CAS  Article  Google Scholar 

  7. Neckameyer, W. S. Learn. Mem. 5, 157–165 (1998).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Correspondence to Aki Ejima.

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Ejima, A. Lessons from heartbreak. Nature 489, 38–39 (2012).

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