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Genetics

The rate of human mutation

A comprehensive analysis of human spontaneous mutation has revealed a strong influence of paternal age, suggesting a link between an increasing number of older fathers and the rise in disorders such as autism. See Article p.471

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References

  1. Kong, A. et al. Nature 488, 471–475 (2012).

    ADS  CAS  Article  Google Scholar 

  2. Keightley, P. D. Genetics 190, 295–304 (2012).

    Article  Google Scholar 

  3. Shimmin, L. C., Chang, B. H.-J. & Li, W.-H. Nature 362, 745–747 (1993).

    ADS  CAS  Article  Google Scholar 

  4. Crow, J. F. Proc. Natl Acad. Sci. USA 94, 8380–8386 (1997).

    ADS  CAS  Article  Google Scholar 

  5. Shabalina, S. A., Ogurtsov, A. Y., Kondrashov, V. A. & Kondrashov, A. S. Trends Genet. 17, 373–376 (2001).

    CAS  Article  Google Scholar 

  6. Goriely, A. & Wilkie, A. O. Am. J. Hum. Genet. 90, 175–200 (2012).

    CAS  Article  Google Scholar 

  7. Sanders, S. J. et al. Nature 485, 237–241 (2012).

    ADS  CAS  Article  Google Scholar 

  8. Saha, S. et al. PLoS Med. 6, e1000040 (2009).

    Article  Google Scholar 

  9. Shabalina, S. A., Yampolsky, L. Y. & Kondrashov, A. S. Proc. Natl Acad. Sci. USA 94, 13034–13039 (1997).

    ADS  CAS  Article  Google Scholar 

  10. Keyes, K. M. et al. Int. J. Epidemiol. 41, 495–503 (2012).

    Article  Google Scholar 

  11. van Boxtel, R. et al. Carcinogenesis 29, 1290–1297 (2008).

    CAS  Article  Google Scholar 

  12. Wimmer, K. & Etzler, J. Hum. Genet. 124, 105–122 (2008).

    Article  Google Scholar 

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Correspondence to Alexey Kondrashov.

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Kondrashov, A. The rate of human mutation. Nature 488, 467–468 (2012). https://doi.org/10.1038/488467a

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