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Structural biology

Dynamic binding

Nature volume 488, pages 165–166 (2012)Cite this article

Nuclear magnetic resonance spectroscopy has been used to establish a vital role for protein motion in the formation of a protein–DNA complex. The finding potentially opens up fresh approaches for modifying protein function. See Letter p.236

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Figure 1: Conformational entropy can modulate protein–DNA binding.

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Authors and Affiliations

  1. Andrew J. Baldwin and Lewis E. Kay are in the Departments of Molecular Genetics, Biochemistry, and Chemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.,

    Andrew J. Baldwin & Lewis E. Kay

  2. L.E.K. is also at the Hospital for Sick Children, Toronto.,

    Lewis E. Kay

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  1. Andrew J. Baldwin
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  2. Lewis E. Kay
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Correspondence to Lewis E. Kay.

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Baldwin, A., Kay, L. Dynamic binding. Nature 488, 165–166 (2012). https://doi.org/10.1038/488165a

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