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Chemical biology

Greasy tags for protein removal

Most proteins in the human body are difficult targets for small-molecule drugs. This problem may have been overcome with the discovery of molecules that induce protein degradation, suggesting fresh, modular approaches to drug discovery.

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Figure 1: Hydrophobic tags for protein degradation.


  1. Neklesa, T. K. et al. Nature Chem. Biol. 7, 538–543 (2011).

    Article  CAS  Google Scholar 

  2. Tae, H. S. et al. ChemBioChem 13, 538–541 (2012).

    Article  CAS  Google Scholar 

  3. Long, M. J. C., Gollapalli, D. R. & Hedstrom, L. Chem. Biol. 19, 629–637 (2012).

    Article  CAS  Google Scholar 

  4. Russ, A. P. & Lampel, S. Drug Discov. Today 10, 1607–1610 (2005).

    Article  Google Scholar 

  5. Kauffman, M. G., Molineaux, C. J., Kirk, C. J. & Crews, C. M. in Cancer: Principles & Practice of Oncology (eds DeVita, V. T. Jr, Lawrence, T. S. & Rosenberg, S. A.) 441–449 (Lippincott Williams & Wilkins, 2011).

    Google Scholar 

  6. Schneekloth, J. S. Jr et al. J. Am. Chem. Soc. 126, 3748–3754 (2004).

    Article  CAS  Google Scholar 

  7. Kleiner, R. E., Dumelin, C. E. & Liu, D. R. Chem. Soc. Rev. 40, 5707–5717 (2011).

    Article  CAS  Google Scholar 

  8. Clark, M. A. et al. Nature Chem. Biol. 5, 647–654 (2009).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Craig M. Crews.

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Neklesa, T., Crews, C. Greasy tags for protein removal. Nature 487, 308–309 (2012).

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