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Chemical biology

Greasy tags for protein removal

Most proteins in the human body are difficult targets for small-molecule drugs. This problem may have been overcome with the discovery of molecules that induce protein degradation, suggesting fresh, modular approaches to drug discovery.

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Figure 1: Hydrophobic tags for protein degradation.

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Correspondence to Craig M. Crews.

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Neklesa, T., Crews, C. Greasy tags for protein removal. Nature 487, 308–309 (2012). https://doi.org/10.1038/487308a

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