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Performance enhancement: Superhuman athletes


Enhancements such as doping are illegal in sport — but if all restrictions were lifted, science could push human performance to new extremes.

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  1. Meinhardt, U. et al. Ann. Intern. Med. 152, 568–577 (2010).

    Article  Google Scholar 

  2. Buick, F. J., Gledhill, N., Froese, A. B., Spriet, L. & Meyers, E. C. J. Appl. Physiol. 48, 636–642 (1980).

    Article  CAS  Google Scholar 

  3. Williams, M. H., Wesseldine, S., Somma, T. & Schuster, R. Med. Sci. Sports Exerc. 13, 169–175 (1981).

    CAS  PubMed  Google Scholar 

  4. Schuler, B. et al. FASEB J. (2012).

  5. Engan, H. K., Jones, A. M., Ehrenberg, F. & Schagatay, E. Respir. Physiol. Neurobiol. 182, 53–59 (2012).

    Article  CAS  Google Scholar 

  6. Montgomery, H. E. et al. Nature 393, 221–222 (1998).

    Article  ADS  CAS  Google Scholar 

  7. Williams, A. G. et al. Med. Sci. Sports Exerc. 37, 944–948 (2005).

    CAS  PubMed  Google Scholar 

  8. Barton-Davis, E. R., Shoturma, D. I., Musaro, A., Rosenthal, N. & Sweeney, H. L. Proc. Natl Acad. Sci. USA 95, 15603–15607 (1998).

    Article  ADS  CAS  Google Scholar 

  9. Narkar, V. A. et al. Cell 134, 405–415 (2008).

    Article  CAS  Google Scholar 

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Thompson, H. Performance enhancement: Superhuman athletes. Nature 487, 287–289 (2012).

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