Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Actin' dangerously

Recognition of aberrant cell death is a crucial function of the immune system. It seems that one way in which immune cells identify damage is by sensing actin, an abundant intracellular protein.

Your institute does not have access to this article

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: DNGR-1 recognition of filamentous actin triggers cross-presentation.


  1. Rock, K. L., Lai, J. J. & Kono, H. Immunol. Rev. 243, 191–205 (2011).

    CAS  Article  Google Scholar 

  2. Seong, S. Y. & Matzinger, P. Nature Rev. Immunol. 4, 469–478 (2004).

    CAS  Article  Google Scholar 

  3. Ahrens, S. et al. Immunity 36, 635–645 (2012).

    CAS  Article  Google Scholar 

  4. Zhang, J. G. et al. Immunity 36, 646–657 (2012).

    CAS  Article  Google Scholar 

  5. Osorio, C. & Reis e Sousa, C. Immunity 34, 651–664 (2011).

    CAS  Article  Google Scholar 

  6. Sancho, D. et al. J. Clin. Invest. 118, 2098–2110 (2008).

    CAS  Article  Google Scholar 

  7. Huysamen, C. et al. J. Biol. Chem. 283, 16693–16701 (2008).

    CAS  Article  Google Scholar 

  8. Caminschi, I. et al. Blood 112, 3264–3273 (2008).

    CAS  Article  Google Scholar 

  9. Sancho, D. et al. Nature 458, 899–903 (2009).

    ADS  CAS  Article  Google Scholar 

  10. Zelenay, S. et al. J. Clin. Invest. 122, 1615–1627 (2012).

    CAS  Article  Google Scholar 

  11. Iborra, S. et al. J. Clin. Invest. 122, 1628–1643 (2012).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Gordon D. Brown.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Brown, G. Actin' dangerously. Nature 485, 589–590 (2012).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing