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Immunology

Actin' dangerously

Recognition of aberrant cell death is a crucial function of the immune system. It seems that one way in which immune cells identify damage is by sensing actin, an abundant intracellular protein.

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Figure 1: DNGR-1 recognition of filamentous actin triggers cross-presentation.

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Correspondence to Gordon D. Brown.

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Brown, G. Actin' dangerously. Nature 485, 589–590 (2012). https://doi.org/10.1038/485589a

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