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Cardiovascular Biology

Escaped DNA inflames the heart

High blood pressure can damage heart muscle cells and their mitochondrial organelles. DNA from degraded mitochondria has been shown to trigger inflammation leading to heart failure. See Letter p.251

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Figure 1: A stressed heart cell.


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Correspondence to Richard N. Kitsis.

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Konstantinidis, K., Kitsis, R. Escaped DNA inflames the heart. Nature 485, 179–180 (2012).

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