Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Drug discovery

Time in a bottle

A biological clock synchronizes animal behaviour and physiology with Earth's 24-hour rotation. Drugs targeting the clock's 'gears' show promise for treating obesity and other metabolic disorders. See Article p.62 & Letter p.123

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Janszky, I. et al. Sleep Med. 13, 237–242 (2012).

    Article  Google Scholar 

  2. 2

    Solt, L. A. et al. Nature 485, 62–68 (2012).

    ADS  CAS  Article  Google Scholar 

  3. 3

    Cho, H. et al. Nature 485, 123–127 (2012).

    ADS  CAS  Article  Google Scholar 

  4. 4

    Balsalobre, A., Damiola, F. & Schibler, U. Cell 93, 929–937 (1998).

    CAS  Article  Google Scholar 

  5. 5

    Hughes, M. E. et al. PLoS Genet. 5, e1000442 (2009).

    Article  Google Scholar 

  6. 6

    Lazar, M. A., Hodin, R. A., Darling, D. S. & Chin, W. W. Mol. Cell. Biol. 9, 1128–1136 (1989).

    CAS  Article  Google Scholar 

  7. 7

    Preitner, N. et al. Cell 110, 251–260 (2002).

    CAS  Article  Google Scholar 

  8. 8

    Raspé, E. et al. J. Lipid Res. 43, 2172–2179 (2002).

    Article  Google Scholar 

  9. 9

    Le Martelot, G. et al. PLoS Biol. 7, e1000181 (2009).

    Article  Google Scholar 

  10. 10

    Wang, J. & Lazar, M. A. Mol. Cell. Biol. 28, 2213–2220 (2008).

    CAS  Article  Google Scholar 

  11. 11

    Raghuram, S. et al. Nature Struct. Mol. Biol. 14, 1207–1213 (2007).

    CAS  Article  Google Scholar 

  12. 12

    Yin, L. et al. Science 318, 1786–1789 (2007).

    ADS  CAS  Article  Google Scholar 

  13. 13

    Wu, N. et al. Genes Dev. 23, 2201–2209 (2009).

    CAS  Article  Google Scholar 

  14. 14

    Liu, A. C. et al. PLoS Genet. 4, e1000023 (2008).

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Joseph Bass.

Ethics declarations

Competing interests

Joseph Bass provides consulting and speakers bureau services to Merck and to Gerhson Lehrman Group. He has received research funding from Amylin Pharmaceuticals, Eli Lilly and Takeda Pharmaceuticals. He is a member of the advisory board and a stockholder of Reset Therapeutics. Neither of these companies is mentioned, or specifically alluded to, in this article.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Bass, J. Time in a bottle. Nature 485, 45–46 (2012). https://doi.org/10.1038/485045a

Download citation

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing