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Protein engineering

Tighter ties that bind

Nature volume 484, pages 463–464 (2012)Cite this article

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A stepwise process of mutation and structural analysis has modulated a flexible binding interface of an immune-cell signalling protein, interleukin-2, and generated mutant proteins with enhanced anticancer activity. See Article p.529

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Figure 1: Signalling superpowers.

References

  1. Levin, A. M. et al. Nature 484, 529–533 (2012).

    Article  ADS  CAS  Google Scholar 

  2. Malek, T. R. & Castro, I. Immunity 33, 153–165 (2010).

    Article  CAS  Google Scholar 

  3. Wang, X., Rickert, M. & Garcia, K. C. Science 310, 1159–1163 (2005).

    Article  ADS  CAS  Google Scholar 

  4. Arima, N. et al. J. Exp. Med. 176, 1265–1272 (1992).

    Article  CAS  Google Scholar 

  5. Eklund, J. W. & Kuzel, T. M. Curr. Opin. Oncol. 16, 542–546 (2004).

    Article  CAS  Google Scholar 

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  1. Eric T. Boder is in the Department of Chemical and Biomolecular Engineering, University of Tennessee, Knoxville, Tennessee 37996-2200, USA.,

    Eric T. Boder

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  1. Eric T. Boder
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Correspondence to Eric T. Boder.

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Boder, E. Tighter ties that bind. Nature 484, 463–464 (2012). https://doi.org/10.1038/484463a

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