Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Gene expression

Running to stand still

Transcription factors regulate the expression of genes by binding to certain DNA sequences. But the outcome can be markedly different, depending on whether the binding is stable or short-lived. See Letter p.251

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Well-balanced gene expression.


  1. Macarthur, S. et al. Genome Biol. 10, R80 (2009).

    Article  Google Scholar 

  2. Lickwar, C. R., Mueller, F., Hanlon, S. E., McNally, J. G. & Lieb, J. D. Nature 484, 251–255 (2012).

    ADS  CAS  Article  Google Scholar 

  3. Lieb, J. D., Liu, X., Botstein, D. & Brown, P. O. Nature Genet. 28, 327–334 (2001).

    CAS  Article  Google Scholar 

  4. Schermer, U. J., Korber, P. & Hörz, W. Mol. Cell 19, 279–285 (2005).

    CAS  Article  Google Scholar 

  5. Dion, M. F. et al. Science 315, 1405–1408 (2007).

    ADS  CAS  Article  Google Scholar 

  6. van Werven, F., van Teeffelen, H., Holstege, F. & Timmers, H. Nature Struct. Mol. Biol. 16, 1043–1048 (2009).

    CAS  Article  Google Scholar 

  7. Polach, K. J. & Widom, J. J. Mol. Biol. 254, 130–149 (1995).

    CAS  Article  Google Scholar 

  8. Voss, T. C. et al. Cell 146, 544–554 (2011).

    CAS  Article  Google Scholar 

  9. Hao, N. & O'Shea, E. K. Nature Struct. Mol. Biol. 19, 31–39 (2011).

    Article  Google Scholar 

  10. Hager, G. L., McNally, J. G. & Misteli, T. Mol. Cell 35, 741–753 (2009).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding authors

Correspondence to Tommy Kaplan or Nir Friedman.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kaplan, T., Friedman, N. Running to stand still. Nature 484, 171–172 (2012).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing