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Genetics

Broken giant linked to heart failure

Genetic mutations can cause a type of heart disease called dilated cardiomyopathy, by predisposing the organ to enlarge and function poorly. It has now been found that 27% of cases are due to mutations that disrupt the muscle protein titin.

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Figure 1: A molecular ruler.

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Correspondence to Elizabeth M. McNally.

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The author’s spouse receives patent royalties related to techniques used in massively parallel sequencing.

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McNally, E. Broken giant linked to heart failure. Nature 483, 281–282 (2012). https://doi.org/10.1038/483281a

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