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Materials science

Cell environments programmed with light

A combination of two light-induced reactions has been used to attach peptides to a polymeric gel, and then to detach them from it. This feat opens up opportunities for studying the effects of signalling molecules on cell behaviour in vitro.

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Figure 1: Reversible gel patterning.


  1. Fenno, L., Yizhar, O. & Deisseroth, K. Annu. Rev. Neurosci. 34, 389–412 (2011).

    Article  CAS  Google Scholar 

  2. DeForest, C. A. & Anseth, K. S. Angew. Chem. Int. Edn 51, 1816–1819 (2012).

    Article  CAS  Google Scholar 

  3. Morrison, S. J. & Spradling, A. C. Cell 132, 598–611 (2008).

    Article  CAS  Google Scholar 

  4. Sato, T. et al. Nature 459, 262–265 (2009).

    Article  ADS  CAS  Google Scholar 

  5. Khetan, S. & Burdick, J. A. Soft Matter 7, 830–838 (2011).

    Article  ADS  CAS  Google Scholar 

  6. Kloxin, A. M., Kasko, A. M., Salinas, C. N. & Anseth, K. S. Science 324, 59–63 (2009).

    Article  ADS  CAS  Google Scholar 

  7. Khetan, S. & Burdick, J. A. Biomaterials 31, 8228–8234 (2010).

    Article  CAS  Google Scholar 

  8. Hahn, M. S., Miller, J. S. & West, J. L. Adv. Mater. 18, 2679–2684 (2006).

    Article  CAS  Google Scholar 

  9. Wylie, R. G. et al. Nature Mater. 10, 799–806 (2011).

    Article  ADS  CAS  Google Scholar 

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Correspondence to Matthias P. Lutolf.

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Lutolf, M. Cell environments programmed with light. Nature 482, 477–478 (2012).

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