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Cell biology

Collagen secretion explained

Cells package proteins into vesicles for secretion to the extracellular milieu. A study has now identified an enzyme that modifies the packaging machinery to encapsulate unusually large proteins, such as collagen. See Article p.495

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Figure 1: Big vesicles for collagen secretion.


  1. Zanetti, G., Pahuja, K. B., Studer, S., Shim, S. & Schekman, R. Nat. Cell. Biol. 14, 20–28 (2012).

    Article  CAS  Google Scholar 

  2. Jin, L. et al. Nature 482, 495–500 (2012).

    Article  ADS  CAS  Google Scholar 

  3. Stagg, S. M. et al. Cell 134, 474–484 (2008).

    Article  CAS  Google Scholar 

  4. Fath, S., Mancias, J. D., Bi, X. & Goldberg, J. Cell 129, 1325–1336 (2007).

    Article  CAS  Google Scholar 

  5. Komander, D. Biochem. Soc. Trans. 37, 937–953 (2009).

    Article  CAS  Google Scholar 

  6. Saito, K. et al. Cell 136, 891–902 (2009).

    Article  CAS  Google Scholar 

  7. Wilson, D. G. et al. J. Cell Biol. 193, 935–951 (2011).

    Google Scholar 

  8. De Matteis, M. A. & Luini, A. N. Engl. J. Med. 365, 927–938 (2011).

    Article  CAS  Google Scholar 

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Correspondence to David J. Stephens.

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Stephens, D. Collagen secretion explained. Nature 482, 474–475 (2012).

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