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Structural biology

Ion channel in the spotlight

When expressed in neurons, channelrhodopsin proteins allow the cells' electrical activity to be controlled by light. The structure of one such protein will guide efforts to make better tools for controlling neurons. See Article p.369

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Figure 1: Structure of a closed light-gated cation channel.

References

  1. Miesenböck, G. Annu. Rev. Cell Dev. Biol. 27, 731–758 (2011).

    Article  Google Scholar 

  2. Kato, H. E. et al. Nature 482, 369–374 (2012).

    ADS  CAS  Article  Google Scholar 

  3. Nagel, G. et al. Science 296, 2395–2398 (2002).

    ADS  CAS  Article  Google Scholar 

  4. Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G. & Deisseroth, K. Nature Neurosci. 8, 1263–1268 (2005).

    CAS  Article  Google Scholar 

  5. Deisseroth, K. Nature Meth. 8, 26–29 (2011).

    CAS  Article  Google Scholar 

  6. Zhang, F. et al. Cell 147, 1446–1457 (2011).

    CAS  Article  Google Scholar 

  7. Kleinlogel, S. et al. Nature Meth. 8, 1083–1088 (2011).

    CAS  Article  Google Scholar 

  8. Müller, M., Bamann, C., Bamberg, E. & Kühlbrandt, W. J. Mol. Biol. 414, 86–95 (2011).

    Article  Google Scholar 

  9. Poulsen, H. & Nissen, P. Science 335, 416–417 (2012).

    ADS  CAS  Article  Google Scholar 

Download references

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Correspondence to Oliver P. Ernst or Thomas P. Sakmar.

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Ernst, O., Sakmar, T. Ion channel in the spotlight. Nature 482, 318–319 (2012). https://doi.org/10.1038/482318a

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