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Molecular motors

A staggering giant

Nature volume 482, pages 44–45 (2012)Cite this article

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The protein dynein 'walks' along filaments to transport various cargoes within the cell. Two studies reveal that, unlike other motor proteins, dynein's steps are not strictly coordinated.

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Figure 1: Stepping patterns in motor proteins.

References

  1. DeWitt, M. A., Chang, A. Y., Combs, P. A. & Yildiz, A. Science 335, 221–225 (2012).

    Article  ADS  CAS  Google Scholar 

  2. Qiu, W. et al. Nature Struct. Mol. Biol. http://dx.doi.org/10.1038/nsmb.2205 (2012).

  3. Vallee, R. B., Williams, J. C., Varma, D. & Barnhart, L. E. J. Neurobiol. 58, 189–200 (2004).

    Article  CAS  Google Scholar 

  4. Sakakibara, H. & Oiwa, K. FEBS J. 278, 2964–2979 (2011).

    Article  CAS  Google Scholar 

  5. Toba, S., Watanabe T. M., Yamaguchi-Okimoto, L., Toyoshima, Y. Y. & Higuchi, H. Proc. Natl Acad. Sci. USA 103, 5741–5745 (2006).

    Article  ADS  CAS  Google Scholar 

  6. Gennerich, A., Carter, A. P., Reck-Peterson, S. L. & Vale, R. D. Cell 131, 952–965 (2007).

    Article  CAS  Google Scholar 

  7. Warshaw, D. M. et al. Biophys. J. 88, L30–L32 (2005).

    Article  CAS  Google Scholar 

  8. Churchman, L. S., Ökten, Z., Rock, R. S., Dawson, J. F. & Spudich, J. A. Proc. Natl Acad. Sci. USA 102, 1419–1423 (2005).

    Article  ADS  CAS  Google Scholar 

  9. Rosenfeld, S. S., Fordyce, P. M., Jefferson, G. M., King, P. H. & Block, S. M. J. Biol. Chem. 278, 18550–18556 (2003).

    Article  CAS  Google Scholar 

  10. Ori-McKenney, K. M., Xu, J., Gross, S. P. & Vallee, R. B. Nature Cell Biol. 12, 1228–1234 (2010).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Wilhelm J. Walter and Stefan Diez are at the B CUBE — Center for Molecular Bioengineering, Technische Universität Dresden and at the Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.,

    Wilhelm J. Walter & Stefan Diez

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  1. Wilhelm J. Walter
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  2. Stefan Diez
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Correspondence to Wilhelm J. Walter or Stefan Diez.

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Walter, W., Diez, S. A staggering giant. Nature 482, 44–45 (2012). https://doi.org/10.1038/482044a

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