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Reward alters specific connections

How does the brain couple a fleeting sensory input to a delayed reward during learning? A study in locusts shows that coincident firing of neurons can 'mark' a neuronal connection for later modulation. See Article p.47

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Figure 1: Modulation of neuronal connections.


  1. Bain, A. Mind and Body (Appleton, 1877; reformatted Univ. Michigan Library, 2006).

    Google Scholar 

  2. Hebb, D. O. The Organization of Behavior (Psychology Press, 2002).

    Google Scholar 

  3. Cassenaer, S. & Laurent, G. Nature 482, 47–52 (2012).

    Article  ADS  CAS  Google Scholar 

  4. Bliss, T. V. P. & Lømo, T. J. Physiol. (Lond.) 232, 331–356 (1973).

    Article  CAS  Google Scholar 

  5. Markram, H., Gerstner, W. & Sjöström, P. J. Front. Synaptic Neurosci. 3, 4 (2011).

    Article  Google Scholar 

  6. Morrison, A., Aertsen, A. & Diesmann, M. Neural Comput. 19, 1437–1467 (2007).

    Article  MathSciNet  Google Scholar 

  7. Drew, P. J. & Abbott, L. F. Proc. Natl Acad. Sci. USA 103, 8876–8881 (2006).

    Article  ADS  CAS  Google Scholar 

  8. Ito, I., Ong, R. C., Raman, B. & Stopfer, M. Commun. Integr. Biol. 1, 170–171 (2008).

    Article  Google Scholar 

  9. Pawlak, V., Wickens, J. R., Kirkwood, A. & Kerr, J. N. Front. Synaptic Neurosci. 2, 146 (2010).

    Article  Google Scholar 

  10. Degen, J., Gewecke, M. & Roeder, T. Br. J. Pharmacol. 130, 587–594 (2000).

    Article  CAS  Google Scholar 

  11. Sinakevitch, I., Mustard, J. A. & Smith, B. H. PLoS ONE 6, e14536 (2011).

    Article  ADS  CAS  Google Scholar 

  12. Linster, C., Nai, Q. & Ennis, M. J. Neurophysiol. 105, 1432–1443 (2011).

    Article  Google Scholar 

  13. Shea, S. D., Katz, L. C. & Mooney, R. J. Neurosci. 28, 10711–10719 (2008).

    Article  CAS  Google Scholar 

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Correspondence to Timothy E. Holy.

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Holy, T. Reward alters specific connections. Nature 482, 39–41 (2012).

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