Most drug candidates fail clinical trials, in many cases because the compounds have less than optimal physico-chemical properties. A new method for assessing the 'drug-likeness' of compounds might help to remedy the situation.
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References
Bickerton, G. R., Paolini, G. V., Besnard, J., Muresan, S. & Hopkins, A. L. Nature Chem. 4, 90–98 (2012).10.1038/nchem.1243
Lipinski, C. A., Lombardo, F., Dominy, B. W. & Feeney, P. J. Adv. Drug Delivery Rev. 23, 3–25 (1997).
Wenlock, M. C., Austin, R. P., Barton, P., Davis, A. M. & Leeson, P. D. J. Med. Chem. 46, 1250–1256 (2003).
Hughes, J. D. et al. Bioorg. Med. Chem. Lett. 18, 4872–4875 (2008).
Luker, T. et al. Bioorg. Med. Chem. Lett. 21, 5673–5679 (2011).
Leeson, P. D. & Springthorpe, B. Nature Rev. Drug Discov. 6, 881–890 (2007).
Leeson. P. D. & St-Gallay, S. A. Nature Rev. Drug Discov. 10, 749–765 (2011).
Hann, M. M. Med. Chem. Commun. 2, 349–355 (2011).
Wager, T. T. et al. ACS Chem. Neurosci. 1, 435–449 (2010).
Lajiness, M. S., Maggiora, G. M. & Shanmugasundaram, V. J. Med. Chem. 47, 4891–4896 (2004).
Teague, S. J., Davis, A. M., Leeson, P. D. & Oprea, T. Angew. Chem. Int. Edn 38, 3743–3748 (1999).
Bunnage, M. E. Nature Chem. Biol. 7, 335–339 (2011).
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Leeson, P. Chemical beauty contest. Nature 481, 455–456 (2012). https://doi.org/10.1038/481455a
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DOI: https://doi.org/10.1038/481455a
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