Genomic analyses of tumours of the childhood cancer retinoblastoma reveal a low mutation rate, challenging the view that genomic instability is crucial for its progression. The work also identifies a new therapeutic target. See Article p.329
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Sage, J., Cleary, M. The path to retinoblastoma. Nature 481, 269–270 (2012). https://doi.org/10.1038/481269a