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Behavioural effects of cocaine reversed

Cocaine use causes lasting changes in behaviour by altering the strength of connections between neurons. The finding that these changes can be reversed in mice suggests strategies that could be used to treat drug addiction. See Letter p.71

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Figure 1: Normalizing the locomotor response to cocaine in mice.


  1. Pascoli, V. et al. Nature 481, 71–75 (2012).

    Article  ADS  CAS  Google Scholar 

  2. Robinson, T. E. & Berridge, K. C. Phil. Trans. R. Soc. Lond. B 363, 3137–3146 (2008).

    Article  Google Scholar 

  3. Wolf, M. E. & Ferrario, C. R. Neurosci. Biobehav. Rev. 35, 185–211 (2010).

    Article  CAS  Google Scholar 

  4. Sesack, S. R. & Grace, A. A. Neuropsychopharmacology 35, 27–47 (2010).

    Article  Google Scholar 

  5. Koob, G. F. & Volkow, N. D. Neuropsychopharmacology 35, 217–238 (2010).

    Article  Google Scholar 

  6. Conrad, K. L. et al. Nature 454, 118–121 (2008).

    Article  ADS  CAS  Google Scholar 

  7. Moussawi, K. et al. Proc. Natl Acad. Sci. USA 108, 385–390 (2011).

    Article  ADS  CAS  Google Scholar 

  8. Feil, J. & Zangen, A. Neurosci. Biobehav. Rev. 34, 559–574 (2010).

    Article  Google Scholar 

  9. Clark, D. & White, F. J. Synapse 1, 347–388 (1987).

    Article  ADS  CAS  Google Scholar 

  10. Seif, T., Makriyannis, A., Kunos, G., Bonci, A. & Hopf, F. W. Neuroscience 193, 21–23 (2011).

    Article  CAS  Google Scholar 

  11. Koya, E. et al. Nature Neurosci. 12, 1069–1073 (2009).

    Article  CAS  Google Scholar 

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Correspondence to Marina E. Wolf.

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Wolf, M. Behavioural effects of cocaine reversed. Nature 481, 36–37 (2012).

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