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Noise rules

The idea that gene variants alone control an organism's traits is overly simple. A study of the effects of gene interactions on the outcomes of random variation in gene expression reveals the complex reality. See Letter p.250

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Figure 1: Noise regulons and gene expression.


  1. Burga, A., Casanueva, M. O. & Lehner, B. Nature 480, 250–253 (2011).

    Article  CAS  ADS  Google Scholar 

  2. Raj, A., Rifkin, S. A., Andersen, E. & van Oudenaarden, A. Nature 463, 913–918 (2010).

    Article  CAS  ADS  Google Scholar 

  3. Elowitz, M. B., Levine, A. J., Siggia, E. D. & Swain, P. S. Science 297, 1183–1186 (2002).

    Article  CAS  ADS  Google Scholar 

  4. Rutherford, S. L. & Lindquist, S. Nature 396, 336–342 (1998).

    Article  CAS  ADS  Google Scholar 

  5. Stewart-Ornstein, J., Weissman, J. S. & El-Samad, H. Mol. Cell (in the press).

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Correspondence to Hana El-Samad or Jonathan S. Weissman.

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El-Samad, H., Weissman, J. Noise rules. Nature 480, 188–189 (2011).

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