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Organic chemistry

A radical approach to diversity

Compounds containing the trifluoromethyl group have many uses, but their isomers must often be made using different multi-step routes. Two studies now show how several isomers can be made by the same route. See Letter p.224

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Figure 1: Approaches for making trifluoromethylated compounds.


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Correspondence to Andrew T. Parsons or Stephen L. Buchwald.

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Competing interests

S.L.B. is a consultant for a company partially owned by David MacMillan. S.L.B. and David MacMillan co-teach a short course that they have given together at pharmaceutical companies.

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Parsons, A., Buchwald, S. A radical approach to diversity. Nature 480, 184–185 (2011).

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