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Immunology

A heavyweight knocked out

Caspase-1 is one of the main culprits behind sepsis, a form of systemic inflammation. The related enzyme caspase-11 is also involved, but the relative roles of the two proteins have been confusing, until now. See Letter p.117

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Figure 1: Caspase-1 versus caspase-11.

References

  1. Martin, G. S. et al. N. Engl. J. Med. 348, 1546–1554 (2003).

    Article  Google Scholar 

  2. Kayagaki, N. et al. Nature 479, 117–121 (2011).

    ADS  CAS  Article  Google Scholar 

  3. Fuentes-Prior, P. & Salvesen, G. S. Biochem. J. 384, 201–232 (2004).

    CAS  Article  Google Scholar 

  4. Green, D. R. Means to an End: Apoptosis and Other Cell Death Mechanisms (Cold Spring Harbor Lab. Press, 2011).

    Google Scholar 

  5. Schroder, K. & Tschopp, J. Cell 140, 821–832 (2010).

    CAS  Article  Google Scholar 

  6. Li, P. et al. Cell 80, 401–411 (1995).

    CAS  Article  Google Scholar 

  7. Wang, S. et al. Cell 92, 501–509 (1998).

    CAS  Article  Google Scholar 

  8. Lamkanfi, M. et al. Blood 113, 2742–2745 (2009).

    CAS  Article  Google Scholar 

  9. Lamkanfi, M. et al. J. Immunol. 185, 4385–4392 (2010).

    CAS  Article  Google Scholar 

  10. Keane, T. M. et al. Nature 477, 289–294 (2011).

    ADS  CAS  Article  Google Scholar 

Download references

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Correspondence to Douglas R. Green.

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Green, D. A heavyweight knocked out. Nature 479, 48–50 (2011). https://doi.org/10.1038/479048a

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