Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


Suicide of a protein

Plants and fungi follow a complex route to make the vitamin thiamine for carbohydrate metabolism. One of the pathway's protein participants turns out to be a surprising player, sacrificing its own activity in the process. See Letter p.542

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Incorporation of sulphur into a thiamine precursor.


  1. Chatterjee, A. et al. Nature 478, 542–546 (2011).

    Article  ADS  CAS  Google Scholar 

  2. Chatterjee, A., Jurgenson, C. T., Schroeder, F. C., Ealick, S. E. & Begley, T. P. J. Am. Chem. Soc. 129, 2914–2922 (2007).

    Article  CAS  Google Scholar 

  3. Sedgwick, B., Robins, P., Totty, N. & Lindahl, T. J. Biol. Chem. 263, 4430–4433 (1988).

    CAS  PubMed  Google Scholar 

  4. Faou, P. & Tropschug, M. J. Mol. Biol. 344, 1147–1157 (2004).

    Article  CAS  Google Scholar 

  5. Machado, C. R. et al. J. Mol. Biol. 273, 114–121 (1997).

    Article  CAS  Google Scholar 

  6. Ruiz-Roldán, C. et al. Fungal Genet. Biol. 45, 6–16 (2008).

    Article  Google Scholar 

  7. Medina-Silva, R. et al. Res. Microbiol. 157, 275–281 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Peter Roach.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Roach, P. Suicide of a protein. Nature 478, 463–464 (2011).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing