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Biochemistry

Suicide of a protein

Plants and fungi follow a complex route to make the vitamin thiamine for carbohydrate metabolism. One of the pathway's protein participants turns out to be a surprising player, sacrificing its own activity in the process. See Letter p.542

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Figure 1: Incorporation of sulphur into a thiamine precursor.

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Correspondence to Peter Roach.

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Roach, P. Suicide of a protein. Nature 478, 463–464 (2011). https://doi.org/10.1038/478463a

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