Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Chemical biology

Many faces of a cancer-supporting protein

A Correction to this article was published on 26 October 2011

The protein Hsp90 is a target of promising anticancer drugs. An analysis of the components of Hsp90 complexes in tumours reveals a path that may lead to predictive assays of drug sensitivity in cancer patients.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Analysis of Hsp90-containing complexes using chemical proteomics.


  1. Whitesell, L., Mimnaugh, E. G., De Costa, B., Myers, C. E. & Neckers, L. M. Proc. Natl Acad. Sci. USA 91, 8324–8328 (1994).

    Article  ADS  CAS  Google Scholar 

  2. Workman, P. Cancer Lett. 206, 149–157 (2004).

    Article  CAS  Google Scholar 

  3. Moulick, K. et al. Nature Chem. Biol. (2011).

  4. Modi, S. et al. Clin. Cancer Res. 17, 5132–5139 (2011).

    Article  CAS  Google Scholar 

  5. Sequist, L. V. et al. J. Clin. Oncol. 28, 4953–4960 (2010).

    Article  CAS  Google Scholar 

  6. Neckers, L. & Workman, P. Clin. Cancer Res. (in the press).

  7. McClellan, A. J. et al. Cell 131, 121–135 (2007).

    Article  CAS  Google Scholar 

  8. Zhao, R. et al. Cell 120, 715–727 (2005).

    Article  CAS  Google Scholar 

  9. Maloney, A. et al. Cancer Res. 67, 3239–3253 (2007).

    Article  CAS  Google Scholar 

  10. Kamal, A. et al. Nature 425, 407–410 (2003).

    Article  ADS  CAS  Google Scholar 

  11. Tillotson, B. et al. J. Biol. Chem. 285, 39835–39843 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Paul Workman.

Ethics declarations

Competing interests

J.F.D. is a PhD student at and P.W. is an employee of the Institute of Cancer Research, which has a commercial interest in Hsp90 inhibitors. P.W. has been involved in a funded research collaboration on Hsp90 inhibitors with Vernalis Ltd. Intellectual property arising from the Hsp90 programme has been licensed to Vernalis and Novartis. P.W. has been a consultant to Novartis.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Darby, J., Workman, P. Many faces of a cancer-supporting protein. Nature 478, 334–335 (2011).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer