Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Molecular medicine

Defence against oxidative damage

Macular degeneration is a leading cause of blindness in the elderly in the developed world. Hope for prevention and treatment comes from the discovery of a protective mechanism against oxidative damage to the eye. See Letter p.76

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Mechanisms at work in age-related macular degeneration.

References

  1. 1

    Takeda, A. et al. Nature 460, 225–230 (2009).

    CAS  Article  ADS  Google Scholar 

  2. 2

    Weismann, D. et al. Nature 478, 76–81 (2011).

    CAS  Article  ADS  Google Scholar 

  3. 3

    Telander, D. G. Semin. Ophthalmol. 26, 192–197 (2011).

    Article  Google Scholar 

  4. 4

    Crabb, J. W. et al. Proc. Natl Acad. Sci. USA 99, 14682–14687 (2002).

    CAS  Article  ADS  Google Scholar 

  5. 5

    Klein, R. J. et al. Science 308, 385–389 (2005).

    CAS  Article  ADS  Google Scholar 

  6. 6

    Haines, J. L. et al. Science 308, 419–421 (2005).

    CAS  Article  ADS  Google Scholar 

  7. 7

    Edwards, A. O. et al. Science 308, 421–424 (2005).

    CAS  Article  ADS  Google Scholar 

  8. 8

    Miller, Y. I. et al. Circ. Res. 108, 235–248 (2011).

    CAS  Article  Google Scholar 

  9. 9

    Suzuki, M. et al. Mol. Vision 13, 772–778 (2007).

    CAS  Google Scholar 

  10. 10

    Hollyfield, J. G. et al. Nature Med. 14, 194–198 (2008).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Victor L. Perez.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Cruz-Guilloty, F., Perez, V. Defence against oxidative damage. Nature 478, 42–43 (2011). https://doi.org/10.1038/478042a

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing