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Cardiovascular biology

Heart fails without pump partner

Mishandling of calcium ions by cardiac cells causes the heart to malfunction. The discovery of a crucial modification to a calcium pump inside the cell opens up a potential way to correct this. See Letter p.601

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Figure 1: The SERCA2a calcium pump and its modification by SUMO1.


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Correspondence to Sudha K. Shenoy or Howard A. Rockman.

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Competing interests

H.A.R. is a scientific co-founder of and consultant for Trevena Inc., a company that is developing G-protein-coupled-receptor-targeted drugs.

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Shenoy, S., Rockman, H. Heart fails without pump partner. Nature 477, 546–547 (2011).

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