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Structural biology

Snapshot of a signalling complex

G-protein-coupled receptors initiate signalling pathways by forming complexes with agonist molecules and G proteins. The first crystal structure of such a complex is both reassuring and provocative. See Article p.549 & Letter p.611

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Figure 1: Activated receptor–G-protein complex.

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Correspondence to Thue W. Schwartz or Thomas P. Sakmar.

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Schwartz, T., Sakmar, T. Snapshot of a signalling complex. Nature 477, 540–541 (2011). https://doi.org/10.1038/477540a

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